Brain morphology and neurological soft signs in adolescents with first-episode psychosis

Journal article


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Publication Details

Author list: Bombin I
Publisher: Cambridge University Press (CUP): STM Journals
Publication year: 2009
Volume number: 195
Issue number: 3
Start page: 227
End page: 233
Number of pages: 7
ISSN: 0007-1250
Languages: English-Great Britain (EN-GB)


Abstract

Background: Adolescents with first-episode psychosis have increased
severity of neurological soft signs when compared with controls, but it
is unclear whether increased severity of neurological soft signs is an
expression of specific structural brain deficits. Aims: To examine
whether increased severity of neurological soft signs was associated
with decreased brain volumes in adolescents with first-episode
psychosis. Method: Brain scans were obtained for 70 adolescents (less
than 18 years of age) with first-episode psychosis (duration of positive
symptoms less than 6 months). Volumes were assessed using voxel-based
morphometry and through segmentation of anatomical structures. Results:
Increased severity of sensory integration neurological soft signs
correlated with smaller right and left thalamus volume, whereas
increased severity of sequencing of complex motor acts neurological soft
signs correlated with smaller right caudate volume. Conclusions:
Neurological soft signs may be an easy-to-assess marker of
region-specific structural brain deficits in adolescents with
first-episode psychosis.


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Last updated on 2019-13-08 at 00:45