Brain morphology and neurological soft signs in adolescents with first-episode psychosis

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Détails sur la publication

Liste des auteurs: Bombin I
Editeur: Cambridge University Press (CUP): STM Journals
Année de publication: 2009
Numéro du volume: 195
Numéro de publication: 3
Page d'accueil: 227
Dernière page: 233
Nombre de pages: 7
ISSN: 0007-1250
Languages: Anglais-Royaume-Uni (EN-GB)


Résumé

Background: Adolescents with first-episode psychosis have increased
severity of neurological soft signs when compared with controls, but it
is unclear whether increased severity of neurological soft signs is an
expression of specific structural brain deficits. Aims: To examine
whether increased severity of neurological soft signs was associated
with decreased brain volumes in adolescents with first-episode
psychosis. Method: Brain scans were obtained for 70 adolescents (less
than 18 years of age) with first-episode psychosis (duration of positive
symptoms less than 6 months). Volumes were assessed using voxel-based
morphometry and through segmentation of anatomical structures. Results:
Increased severity of sensory integration neurological soft signs
correlated with smaller right and left thalamus volume, whereas
increased severity of sequencing of complex motor acts neurological soft
signs correlated with smaller right caudate volume. Conclusions:
Neurological soft signs may be an easy-to-assess marker of
region-specific structural brain deficits in adolescents with
first-episode psychosis.


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Dernière mise à jour le 2019-13-08 à 00:45