Frontal activity during the digit symbol substitution test determined by multichannel near-infrared spectroscopy

Journal article


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Publication Details

Author list: Canuet L
Publisher: Karger Publishers
Publication year: 2008
Journal: Neuropsychobiology (0302-282X)
Volume number: 57
Issue number: 4
Start page: 151
End page: 158
Number of pages: 8
ISSN: 0302-282X
eISSN: 1423-0224
Languages: English-Great Britain (EN-GB)


Abstract

BACKGROUND: The digit symbol substitution test (DSST) is a clinically
useful and widely accepted tool for the detection of various psychiatric
disorders. Investigating neural activity during the DSST is useful when
considering the relationship between the poor performance on the DSST
and neurocognitive deficits. However, obtaining reliable functional
imaging of the neural mechanisms associated with this test is
challenging due to motion artifacts. AIMS: To circumvent this problem,
we examined frontal lobe activity during the DSST using multichannel
near-infrared spectroscopy, a noninvasive functional imaging technique
that does not interfere with the DSST procedure. METHODS: Twenty-five
healthy volunteers were enrolled in this study. Changes in the
concentration of oxygenated hemoglobin (oxyHb) during the DSST were
determined bilaterally in 52 measurement points (channels) on the
frontal area. RESULTS: We found significant increases in oxyHb in more
than 70% of the channels, with the intensity of the increase being more
pronounced in the left hemisphere. Several channels showed significant
positive correlations between changes in oxyHb and DSST performance.
Some of the channels with a significant increase in oxyHb during the
DSST did not show a correlation with the DSST performance. CONCLUSIONS:
Our findings indicate that the DSST could prove useful as a frontal lobe
stimulating task. Further examinations of DSST/near-infrared
spectroscopy analyses of neural mechanisms in patients with psychiatric
and neurological diseases are necessary to assess its effectiveness in
clinical practice for the evaluation of neuropsychopathology.


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Last updated on 2019-13-08 at 00:45