Relationship of prepulse inhibition to temperament and character in healthy Japanese subjects

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Publication Details

Author list: Canuet L
Publisher: Elsevier: 12 months
Publication year: 2012
Journal: Neuroscience Research (0168-0102)
Volume number: 72
Issue number: 2
Start page: 187
End page: 193
Number of pages: 7
ISSN: 0168-0102
Languages: English-Great Britain (EN-GB)


Abstract

Prepulse inhibition (PPI) of acoustic startle reflex (ASR) and
personality, such as temperament and character, are considered candidate
endophenotypes of schizophrenia. Gene polymorphism studies have
provided evidence that both PPI and self-transcendence (ST) are
polygenetic traits that involve several neurotransmitters, including the
serotonin and dopamine signaling pathways. However, the relationship
between PPI and temperament/character has not been properly addressed to
date. Here, we investigated the link between PPI and
temperament/character in 169 healthy Japanese subjects. A human startle
response monitoring system was used to deliver acoustic startle stimuli
and to record and score the electromyographic activity of the
orbicularis oculi muscle. PPI was evaluated at signal-to-noise ratios
(SnRs: intensity difference between background noise and prepulse) of
+12, +16, and +20 dB. The lead interval (from prepulse onset to pulse
onset) was 120 ms, and Temperament and Character Inventory was used in
both groups. Significant correlations at SnR of +16 and +20 dB to ST
were identified. Our results suggest that impaired sensorimotor gating,
evaluated as lower PPI of ASR, of healthy subjects is correlated with
self transcendence, the character which is closely related with
schizophrenia and schizotypy.


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Last updated on 2019-13-08 at 00:45