Working memory abnormalities in chronic interictal epileptic psychosis and schizophrenia revealed by magnetoencephalography

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Publication Details

Author list: Canuet L
Publisher: Elsevier
Publication year: 2010
Journal: Epilepsy and Behavior (1525-5050)
Journal acronym: E&B
Volume number: 17
Issue number: 1
Start page: 109
End page: 119
Number of pages: 11
ISSN: 1525-5050
Languages: English-Great Britain (EN-GB)


Working memory (WM) deficits are considered a core cognitive dysfunction
in schizophrenia. To determine cognitive abnormalities in chronic
interictal psychosis (CIP), and to assess whether these abnormalities
are distinguishable from those seen in schizophrenia in terms of WM
deficits, we used magnetoencephalography during a WM task performed by
patients with CIP, nonpsychotic epilepsy, and schizophrenia and by
healthy subjects. Multiple Source Beamformer and Brain-Voyager were used
for analysis. In both patients with CIP and those with schizophrenia,
we found dorsolateral prefrontal hyperactivation and left inferior
temporal hypoactivation, as indicated by alpha event-related
desynchronization and synchronization, respectively. Patients with
schizophrenia also showed alpha2 event-related desynchronization in the
mid-prefrontal cortex relative to healthy controls. Direct comparison of
patients with CIP and schizophrenia rendered no difference in
source-power changes. Our findings indicate similar functional cognitive
abnormalities in CIP and schizophrenia in the prefrontal and left
temporal cortex, which supports the possibility that these disorders
share common underlying pathophysiological mechanisms.


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Last updated on 2019-13-08 at 00:45