Early prefrontal activation as a mechanism to prevent forgetting in the context of interference

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Publication Details

Author list: García-Pacios J
Publisher: Elsevier: 12 months
Publication year: 2013
Volume number: 21
Issue number: 6
Start page: 580
End page: 588
Number of pages: 9
ISSN: 1064-7481
Languages: English-Great Britain (EN-GB)


Abstract

Objective: Recent research has focused on interference resolution
deficits as the main cause of short-term memory decreases in aging. To
determine whether activation of brain compensatory mechanisms occur
during the encoding process in older people. Moreover, two different
levels of interference (distraction and interruption) were presented
during the maintenance period to examine how they modulate brain
activity profiles. Design: A delayed match-to-sample task with two
experimental conditions: distraction and interruption. Participants:
Twenty-seven young adults from Complutense University of Madrid and 20
healthy older adults from Complutense Elderly University of Madrid.
Measurements: Magnetoencephalography scans were recorded during the
execution of a working memory interference task. Brain activity sources
from younger and older adults during the encoding stage were compared in
each condition using minimum norm estimation analyses. Results: The
elderly showed enhancement of prefrontal activity during early latencies
of the encoding process in both conditions. In the distraction
condition, enhanced activity was located in left ventrolateral
prefrontal regions, whereas in the interruption condition, enhanced
activity was observed in the right ventral prefrontal areas and anterior
cingulate cortex. Conclusion: Increased recruitment of prefrontal
regions in the elderly might be related to the processing depth of
information, encoding of new information and semantic associations that
are successfully recalled, and with interference resolution and
preparatory control when the level of interference becomes higher. These
prefrontal modulations during early latencies might reflect a higher
top-down control of the encoding process in normal aging to prevent
forgetting.


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Last updated on 2019-13-08 at 00:45