Relationship between measures of inhibitory processes in patients with schizophrenia

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Publication Details

Subtitle: role of substance abuse disorders
Author list: Jurado Barba R
Publisher: Elsevier: 12 months
Publication year: 2011
Journal: Psychiatry Research (0165-1781)
Volume number: 190
Issue number: 2-3
Start page: 187
End page: 192
Number of pages: 6
ISSN: 0165-1781
Languages: English-Great Britain (EN-GB)


Disruption of prepulse inhibition of the startle response (PPI) has been
widely identified in patients with schizophrenia, as well as impairment
in many domains of cognitive functioning. However, there is some
controversy regarding the relationship between PPI and the different
neuropsychological tasks assessing inhibition. This controversy may be
due to the influence of other variables, such as substance abuse. We
aimed to determine whether differences in inhibition in schizophrenia
subjects were related to their pattern of substance use and whether
there was a correlation between the changes in each process. PPI and
neuropsychological functioning were studied in three groups of subjects
with schizophrenia (N=73): tobacco dependents (ToD; n=22), multiple
substance abusers (MSUD; n=31) and non-substance abusers (non-SUD;
n=20). All subjects were assessed using PPI and neuropsychological tests
(Stroop and Wisconsin Card Sorting Test [WCST]). ToD showed better
pre-attentive inhibitory function compared to the other two groups, and
MSUD showed lower resistance to interference. Furthermore, significant
correlations were found between PPI, Stroop, and WCST. Our data suggest
that there is a relationship between the different tasks assessing
inhibition in schizophrenia, being affected by substance abuse history.
We also found differences in inhibition capacity depending on substance
abuse in patients with schizophrenia.


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Last updated on 2019-13-08 at 00:45