Functional impairment as a defining feature of: amnestic MCI cognitive, emotional, and demographic correlates

Journal article


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Publication Details

Author list: Santiago-Ramajo S
Publisher: Cambridge University Press (CUP): STM Journals
Publication year: 2012
Volume number: 24
Issue number: 9
Start page: 1494
End page: 1504
Number of pages: 11
ISSN: 1041-6102
Languages: English-Great Britain (EN-GB)


Background: Early definitions of mild cognitive impairment (MCI)
excluded the presence of functional impairment, with preservation of a
person's ability to perform activities of daily living (ADL) as a
diagnostic criterion. However, recent studies have reported varying
degrees of functional impairment associated with MCI. Hence, we aimed to
test the potential functional impairment associated with MCI and its

Methods: Sixty-nine healthy elderly subjects, 115 amnestic
single-domain MCI subjects (a-MCI), and 111 amnestic multi-domain MCI
subjects (md-MCI) were assessed using a battery of neuropsychological
tests including measures of attention, memory, working memory, executive
functions, language, and depression. Additionally, functional ability
was assessed by both qualitative (WHO-DAS II) and quantitative (CHART)
instruments. Cognitive and functional performance was compared between
groups, and regression analyses were performed to identify predictors of
functional ability.

Results: The md-MCI group was more impaired than the a-MCI group,
and both were more impaired than healthy subjects in all cognitive
measures, in total CHART score, CHART cognitive and mobility subscores,
and WHO-DAS II communication and participation subscales. For the rest
of the functional measures, the md-MCI group was more impaired than
healthy controls. Prediction of functional ability by cognitive measures
was limited to md-MCI subjects and was higher for the CHART than for
the WHO-DAS II. The WHO-DAS II was largely influenced by depressive

Conclusions: Functional impairment is a defining feature of MCI and
is partially dependent on the degree of cognitive impairment.
Quantitative measures of functional ability seem more sensitive to
functional impairment in MCI than qualitative measures, which seem to be
more related to depression.


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Last updated on 2019-13-08 at 00:16