Obsessive Compulsive Disorder as a functional interhemispheric imbalance at the thalamic level

Journal article


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Publication Details

Author list: Leite J, Gonçalves, Ó.F., Carvalho, S., Pocinho, F., Relvas, J., Fregni, F.
Publisher: Elsevier
Publication year: 2011
Volume number: 77
Issue number: 3
Start page: 445
End page: 447
Number of pages: 3
ISSN: 0306-9877
Languages: English-Great Britain (EN-GB)


Obsessive Compulsive Disorder (OCD) involves failures in two main
inhibitory processes, namely cognitive (obsessions) and behavioral
(compulsions). Recent research has supported two cortical-subcortical
pathways on OCD pathogenesis: (a) the frontostriatal loop
(dorsolateral-caudate-striatum-thalamus) responsible for impairments of
behavioral inhibition; (b) the orbitofrontal loop (orbitofrontal, medial
prefrontal and cingulate) responsible for impairments with cognitive
inhibitory processes. These failures in both cognitive and motor
inhibitory systems may mediate several neuropsychological deficits in
these patients, namely memory, attention, planning and decision making.
But are those deficits related to specific hemispheric effects, namely
functional imbalance between hemispheres? In this article we hypothesize
that: (1) OCD patients have an inter-hemispheric functional imbalance,
probably due to inadequate filtering at the thalamic level; (2) the
restoration of inter-hemispheric balance, will be correlative to
symptomatic improvement. © 2011 Elsevier Ltd.


Neuropsychology, Neuroscience, Psychology


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