Obsessive Compulsive Disorder as a functional interhemispheric imbalance at the thalamic level

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Liste des auteurs: Leite J, Gonçalves, Ó.F., Carvalho, S., Pocinho, F., Relvas, J., Fregni, F.
Editeur: Elsevier
Année de publication: 2011
Numéro du volume: 77
Numéro de publication: 3
Page d'accueil: 445
Dernière page: 447
Nombre de pages: 3
ISSN: 0306-9877
Languages: Anglais-Royaume-Uni (EN-GB)


Obsessive Compulsive Disorder (OCD) involves failures in two main
inhibitory processes, namely cognitive (obsessions) and behavioral
(compulsions). Recent research has supported two cortical-subcortical
pathways on OCD pathogenesis: (a) the frontostriatal loop
(dorsolateral-caudate-striatum-thalamus) responsible for impairments of
behavioral inhibition; (b) the orbitofrontal loop (orbitofrontal, medial
prefrontal and cingulate) responsible for impairments with cognitive
inhibitory processes. These failures in both cognitive and motor
inhibitory systems may mediate several neuropsychological deficits in
these patients, namely memory, attention, planning and decision making.
But are those deficits related to specific hemispheric effects, namely
functional imbalance between hemispheres? In this article we hypothesize
that: (1) OCD patients have an inter-hemispheric functional imbalance,
probably due to inadequate filtering at the thalamic level; (2) the
restoration of inter-hemispheric balance, will be correlative to
symptomatic improvement. © 2011 Elsevier Ltd.


Neuropsychology, Neuroscience, Psychology


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